This is another example of how our hobby is growing and expanding the need for a more scientific approach to treating and medicating koi. 
 

"Koi (Cyprinus carpio) are popular companion animals in North America, and the demand for diagnosis and treatment of diseases in pet koi is increasing. Bacterial infections are often observed in sick koi as primary or secondary disease processes, but treatment can be difficult because sick fish often do not eat, making PO administration of antimicrobials unreliable, and IM administration requires handling, which often exacerbates stress and further suppresses the fish's immune system... Danofloxacin is currently used to treat bacterial infections in koi and other pet and aquarium fish species because of the drug's low injection volume, lack of local tissue reaction in other species, wide antimicrobial spectrum in other species, and long dosing interval,1 and the authors frequently use danofloxacin to treat cutaneous bacterial infections and systemic septicemia in koi...Therefore, the purpose of the study reported here was to determine the pharmacokinetics and tissue concentrations of danofloxacin in koi following IM administration of a single dose."
 
https://avmajournals.avma.org/view/journals/ajvr/81/9/ajvr.81.9.708.xml?...